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Controlling Malaria Without Chemicals

August 28, 2019 By EarthWise Leave a Comment

Nearly half of the world’s population lives in areas vulnerable to malaria. The disease kills roughly 450,000 people each year, most of them children and pregnant women. Malaria is spread by Anopheles mosquitoes and, over time, the mosquitoes have been developing resistance to the chemical insecticides that are used to control them. In addition, there is great concern about the toxic side effects of the chemicals used on the mosquitoes.

About 30 years ago, scientists identified a type of bacteria that kills Anopheles, but the mechanism was not understood. As a result, the bacteria could not be replicated or used as an alternative to chemical insecticides.

But now, an international research team, headed by researchers at UC Riverside, has identified the neurotoxin produced by the bacteria and has determined how it kills Anopheles. The work is described in a paper published in Nature Communications.

It took the team 10 years to achieve a breakthrough in understanding the bacteria. Modern gene sequencing techniques were the key.

While many neurotoxins target vertebrates and are highly toxic to humans, the neurotoxin that kills Anopheles mosquitoes does not affect humans, vertebrates, fish, or even other insects. Known as PMP1, the substance is not even toxic to mice when given by direct injection.

The team has applied for a patent on this discovery and hopes to find partners to help them develop the bacteria-based insecticide.

There is a high likelihood that PMP1 actually evolved to kill the Anopheles mosquito. This finding opens the door to new avenues of research into other environmentally friendly insecticides that would be targeted at other disease-spreading pests.

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Controlling deadly malaria without chemicals

Photo, posted June 9, 2018, courtesy of Mario Yardanov via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Your Children’s Yellowstone

January 25, 2019 By EarthWise Leave a Comment

Yellowstone National Park was the first national park in the US and according to some sources, the first in the world. It is the home of charismatic megafauna and stunning geysers that attract over four million visitors a year. It is the only place in the United States where bison and wolves can be seen in great numbers. And it is changing.

Over the next few decades of climate change, Yellowstone will quite likely see increased fire, less forest, expanding grasslands, shallower, warmer waterways, and more invasive plants. All these things will alter how and how many animals move through the landscape. Ecosystems are always changing, but climate change is transforming habitats so quickly that many plants and animals may not be able to make the transition at all.

Since 1948, the average annual temperature in the Greater Yellowstone ecosystem has gone up by 2 degrees Fahrenheit. On balance, winter is 10 days shorter and less cold. The Northern Rockies snowpack has fallen to its lowest level in eight centuries. Summers in the park are warmer, drier, and increasingly prone to fire.

Non-nutritious invasive plants like cheatgrass and desert madwort have replaced nutritious native plants. When plants like these take over, they suck moisture out of the ground early so that bison and elk cannot be sustained throughout the summer.

The behavior of elk and other animals is already changing, with many staying outside the park to nibble lawns and alfalfa fields. In turn, wolves go where the elk go. Forests and waterways are changing as well.

The rapid changes going on at Yellowstone mean that the park that our children and grandchildren will visit in the future is likely to be a very different one from the Yellowstone we remember.

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