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A New Kind Of Antibiotic | Earth Wise

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Antimicrobial resistance is a serious and growing problem for public health.  Over time, more and more types of bacteria have become resistant to known antibiotics making it very difficult to treat various kinds of infections. 

A new group of antibiotics with a unique approach to attacking bacteria has been discovered at McMaster University in Canada, representing a promising new clinical approach in the fight against antimicrobial resistance. 

The newly found corbomycin and the lesser-known complestatin have a never-before-seen way to kill bacteria, namely, breaking the function of the bacterial cell wall. Bacteria have a wall around the outside of their cells that gives them shape and is a source of strength.  Antibiotics like penicillin kill bacteria by preventing building of the wall, but the new antibiotics work by doing the opposite – they prevent the wall from being broken down. Breaking down the cell wall is critical for cells to divide. In order for bacteria to grow and spread, they need to expand and divide. By completely blocking the breakdown of the wall, it is as if the bacterium is trapped in a prison and can’t expand or grow. 

The researchers demonstrated in mice that these new antibiotics can block infections caused by the drug resistant Staphylococcus aureus which is a group of bacteria that can cause many serious infections. 

The researchers believe this new approach can be applied to other antibiotics and lead to the discovery of new ones with different mechanisms of action. This study found one completely new antibiotic, but since then, they have found a few others in the same family that have this same new mechanism. 

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Antibiotics discovered that kill bacteria in a new way

Photo, posted March 15, 2012, courtesy of Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Rare Earths From Mining Waste

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The 17 rare earth elements have become important parts of much of modern technology.  Despite their name, most of these elements are relatively plentiful in the earth’s crust, but because of their geochemical properties they are typically dispersed and not often found concentrated in minerals.  As a result, economically exploitable ore deposits are uncommon.  There are no significant sources in the U.S.

Rare earths play important roles in high-performance magnets, electric motors in vehicles, wind turbines, microphones and speakers, and in portable electronics like cell phones.  As these applications become ever larger, the need for additional sources of rare earths increases.

Researchers at Idaho National Laboratory and Rutgers University have studied a method for extracting rare-earth elements from mining waste that could greatly increase the world’s supply of these valuable materials.

It turns out that large amounts of rare earths exist in phosphogypsum, a waste product from producing phosphoric acid from phosphate rock.  The U.S. alone mined 28 million tons of phosphate rock in 2017.  (Phosphoric acid is used in the production of fertilizers and other products).

The researchers estimate that more than a billion tons of phosphogypsum waste sits in piles at storage sites across the U.S. alone.   World-wide, about 100,000 tons of rare earth elements per year end up in phosphogypsum waste.  This compares to the total current world-wide production of rare earth oxides of 126,000 tons.

The researchers studied methods for extracting the elements from the waste. A method utilizing a common environmental bacterium showed great promise.

There are concerns about residual radioactivity and other environmental issues in dealing with the waste material, but the world’s supply of rare earth elements might become much greater based on this research.

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Critical Materials: Researchers Eye Huge Supply of Rare-Earth Elements from Mining Waste

Photo, posted June 19, 2015, courtesy of David Stanley via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

WAMC Northeast Public Radio

WAMC/Northeast Public Radio is a regional public radio network serving parts of seven northeastern states (more...)