malaria

A Promising Malaria Vaccine | Earth Wise

June 23, 2021 By EarthWise Leave a Comment

Malaria is a parasitic disease transmitted through the bite of female Anopheles mosquitoes. Although the disease is both preventable and treatable, an estimated 435,000 people die of it each year, with the majority being children younger than five. Over 90% of all malaria cases and deaths occur in Africa.

The battle against malaria has mostly centered around the use of bed nets, insecticide spraying and antimalarial drugs. To date, there has not been an effective malaria vaccine available.

That may finally be changing. The first vaccinations have begun in Mali in a phase III trial of a malaria vaccine developed by the University of Oxford. The Oxford vaccine showed an efficacy of 77% over 12 months in a phase IIb trial and the hope is that the phase III trial will lead to the licensing of the vaccine in 2023.

Oxford is partnering with the Serum Institute of India for the manufacturing of the vaccine in order to be able to produce high volumes of low-cost vaccine and provide access to countries where it is required the most. The Serum Institute has committed to the production of more than 200 million doses per year once the vaccine is licensed for use, which will be an adequate supply for children most at risk of malaria in sub-Saharan Africa.

The World Health Organization Malaria Vaccine Technology Roadmap has a goal of a malaria vaccine with at least 75% efficacy. Such a vaccine is needed in order to reach the WHO’s goal of reducing malaria deaths by at least 90% by 2030.

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Promising malaria vaccine enters final stage of clinical testing in West Africa

Photo, posted June 9, 2018, courtesy of Mario Yordanov via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Fighting Malaria With Gene-Drive Technology | Earth Wise

June 8, 2020 By EarthWise Leave a Comment

Malaria continues to be a major health hazard throughout the tropical and subtropical regions of the world. There were 228 million cases of malaria in 2018 and over 400,000 deaths.

Malaria is a mosquito-borne infectious disease spread by 40 of the world’s 3,500 mosquito species. So, efforts to control mosquito populations are the primary strategy to eradicate malaria.

A team led by Imperial College London has created a genetic modification that distorts the sex ratio of a population of Anopheles gambiae mosquitoes using “gene drive” technology. The modification works by using a DNA-cutting enzyme to destroy the X chromosome during the production of sperm, which leads to predominantly male offspring, since females require two X chromosomes. The modification is coupled to a gene drive to allow it to spread through a population in a very effective way. A gene drive is a genetic engineering technology that propagates a particular modification by assuring that a specific form of a gene (or allele) will be transmitted with far more than the natural 50% probability.

The result of this is that mosquitoes produce more male offspring, eventually leading to no females being born and a total collapse in the population. The mosquitoes studied are the main malaria vector in sub-Saharan Africa. The hope is that mosquitoes carrying a sex-distorter gene drive would be released in the future, spreading the male bias with local malaria-carrying populations and causing them to collapse. Only female mosquitoes bite and take blood meals. If the gene drive technology works in the field, it could be a game-changer in the fight to eliminate malaria.

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Malaria mosquitoes eliminated in lab by creating all-male populations

Photo, posted June 20, 2014, courtesy of Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Engineering Mosquitoes | Earth Wise

February 21, 2020 By EarthWise Leave a Comment

Tropical regions grapple with the spread of diseases – such as dengue, yellow fever, zika, chikungunya, and malaria – by mosquitoes. A fairly successful strategy has been the Sterile Insect Technique, which is essentially insect birth control. The process involves rearing large quantities of sterilized male mosquitoes in dedicated facilities, and then releasing them to mate with females in the wild. As they do not produce any offspring, the insect population declines over time.

A problem with this approach is that while mosquitoes create health problems for people, they also play important roles in various ecosystems, such as providing food for bats and other animals. Eliminating mosquito populations on a large scale can trigger major changes in ecosystems.

Recently, an international team of scientists has synthetically engineered mosquitoes that halt the transmission of the dengue virus. They genetically engineered mosquitoes with an antibody “cargo” that gets expressed in the female mosquitoes that spread the dengue virus. Once the female mosquito takes in blood, the antibody is activated which hinders the replication of the virus and prevents its dissemination throughout the mosquito, thereby preventing its transmission to humans. Essentially, what the researchers have done is transfer genes from the human immune system to confer immunity to mosquitoes. The researchers are testing methods to neutralize mosquitoes against other viruses they spread.

This opens up a whole new approach to interrupt mosquito-borne human diseases. Mosquitoes are among the deadliest killers on the planet because they are the messengers that transmit deadly diseases. Until now, the only real solution has been to kill the messenger. The new approach may be a better way to deal with a serious problem.

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Mosquitoes engineered to repel dengue virus

Photo, posted June 20, 2014, courtesy of Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Controlling Malaria Without Chemicals

August 28, 2019 By EarthWise Leave a Comment

Nearly half of the world’s population lives in areas vulnerable to malaria. The disease kills roughly 450,000 people each year, most of them children and pregnant women. Malaria is spread by Anopheles mosquitoes and, over time, the mosquitoes have been developing resistance to the chemical insecticides that are used to control them. In addition, there is great concern about the toxic side effects of the chemicals used on the mosquitoes.

About 30 years ago, scientists identified a type of bacteria that kills Anopheles, but the mechanism was not understood. As a result, the bacteria could not be replicated or used as an alternative to chemical insecticides.

But now, an international research team, headed by researchers at UC Riverside, has identified the neurotoxin produced by the bacteria and has determined how it kills Anopheles. The work is described in a paper published in Nature Communications.

It took the team 10 years to achieve a breakthrough in understanding the bacteria. Modern gene sequencing techniques were the key.

While many neurotoxins target vertebrates and are highly toxic to humans, the neurotoxin that kills Anopheles mosquitoes does not affect humans, vertebrates, fish, or even other insects. Known as PMP1, the substance is not even toxic to mice when given by direct injection.

The team has applied for a patent on this discovery and hopes to find partners to help them develop the bacteria-based insecticide.

There is a high likelihood that PMP1 actually evolved to kill the Anopheles mosquito. This finding opens the door to new avenues of research into other environmentally friendly insecticides that would be targeted at other disease-spreading pests.

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Controlling deadly malaria without chemicals

Photo, posted June 9, 2018, courtesy of Mario Yardanov via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Are Mosquitoes Necessary?

March 1, 2016 By WAMC WEB

The Zika virus epidemic is yet another disease transmitted by mosquitoes. Those tiny insects are responsible for spreading many of the world’s worst diseases such as malaria, dengue fever and yellow fever. According to the World Health Organization, over 400,000 people worldwide died from malaria in 2015.