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Saving The Sumatran Rhino | Earth Wise

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The Sumatran rhinoceros is the smallest and most ancient rhino species and is the only surviving species with hair.  It is critically endangered.  Because of poaching and habitat destruction, there are fewer than 50 of them left in the wild and those are scattered in the rainforests of Sumatra and the Indonesian part of Borneo.  Mating encounters between surviving males and females are increasingly rare.

The last male Sumatran rhino in Malaysia died in 2019 but cell samples from that individual are the basis of an ambitious effort in bioengineering.

Researchers from the Max Delbruck Center in Germany are taking skin cells from the deceased rhino and turning them into stem cells.  The hope is to use these stem cells to derive egg and sperm cells to be the basis of assisted reproduction.  Fertilization would take place in a petri dish.  The resultant embryos would then be carried to term by surrogate rhino mothers.

The researchers have reported success generating induced pluripotent stem cells or IPS cells from the rhino skin samples.  IPS cells are able to divide indefinitely and can transform into any cell type in the body.

The next step is to try to cultivate primordial germ cells – the precursors of eggs and sperm.

This work is going on because it is increasingly difficult to preserve the Sumatran rhino population by gathering together remaining individuals in wildlife Reserves.  Females that have not been pregnant for a long time often become infertile because of cyst growth on their reproductive organs, and some are just too old to bear young.

It may take extraordinary efforts like these to save these animals from extinction.

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A second chance for the Sumatran rhino

Photo, posted April 30, 2008, courtesy of Willem V. Strien via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio

Global Warming And Sea Turtle Births | Earth Wise

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Climate change is a serious threat to species whose sex is determined by temperature.  Among these are sea turtles.  Whether marine turtles are born male or female turns out to depend on the temperature of their nest during incubation.

Sea turtle nests need to be around 84.6 degrees Fahrenheit on average to produce a 50:50 sex ratio for embryos developing in eggs.  If temperatures are higher, embryos predominantly become female.  There is a transitional range of temperatures over which both males and females are produced.  Below that range, only males are produced; above that range, only females are produced.

According to recent research published in the journal Conservation Science and Practice, sand temperatures along the Red Sea exceeded the 84.6-degree threshold in all but one of the sites studied.  Some sites measured nearly 96 degrees.  The Red Sea region is home to five of the world’s seven species of sea turtles, including endangered green turtles and critically endangered hawksbill turtles.

Skewing the sex distribution of a species is a serious threat to the future survival of the population.

The Red Sea findings are similar to observations around the world.  In Florida, sea turtle hatchlings were born 100% female in seven out the past 10 years, and in the other three years, males only made up 10-20% of the brood.  In Australia’s Raine Island, the largest green turtle nesting ground in the Pacific Ocean, the ratio of female to male turtle hatchlings in 2018 was 116:1.

Marine turtles have been around since the late Triassic period and have adapted to previous climate shifts.  But the rapid pace of human-driven climate change is threatening the future survival of these creatures.

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Rising Temperatures Driving a Shift to All-Female Sea Turtle Populations

Photo, posted in October, 2005, courtesy of Frank_am_Main via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Fighting Malaria With Gene-Drive Technology | Earth Wise

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Malaria continues to be a major health hazard throughout the tropical and subtropical regions of the world. There were 228 million cases of malaria in 2018 and over 400,000 deaths. 

Malaria is a mosquito-borne infectious disease spread by 40 of the world’s 3,500 mosquito species.  So, efforts to control mosquito populations are the primary strategy to eradicate malaria.

A team led by Imperial College London has created a genetic modification that distorts the sex ratio of a population of Anopheles gambiae mosquitoes using “gene drive” technology.  The modification works by using a DNA-cutting enzyme to destroy the X chromosome during the production of sperm, which leads to predominantly male offspring, since females require two X chromosomes.  The modification is coupled to a gene drive to allow it to spread through a population in a very effective way.  A gene drive is a genetic engineering technology that propagates a particular modification by assuring that a specific form of a gene (or allele) will be transmitted with far more than the natural 50% probability.

The result of this is that mosquitoes produce more male offspring, eventually leading to no females being born and a total collapse in the population. The mosquitoes studied are the main malaria vector in sub-Saharan Africa.  The hope is that mosquitoes carrying a sex-distorter gene drive would be released in the future, spreading the male bias with local malaria-carrying populations and causing them to collapse.  Only female mosquitoes bite and take blood meals.  If the gene drive technology works in the field, it could be a game-changer in the fight to eliminate malaria.

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Malaria mosquitoes eliminated in lab by creating all-male populations

Photo, posted June 20, 2014, courtesy of Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Engineering Mosquitoes | Earth Wise

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Tropical regions grapple with the spread of diseases – such as dengue, yellow fever, zika, chikungunya, and malaria – by mosquitoes.  A fairly successful strategy has been the Sterile Insect Technique, which is essentially insect birth control. The process involves rearing large quantities of sterilized male mosquitoes in dedicated facilities, and then releasing them to mate with females in the wild. As they do not produce any offspring, the insect population declines over time.

A problem with this approach is that while mosquitoes create health problems for people, they also play important roles in various ecosystems, such as providing food for bats and other animals.  Eliminating mosquito populations on a large scale can trigger major changes in ecosystems.

Recently, an international team of scientists has synthetically engineered mosquitoes that halt the transmission of the dengue virus.  They genetically engineered mosquitoes with an antibody “cargo” that gets expressed in the female mosquitoes that spread the dengue virus.  Once the female mosquito takes in blood, the antibody is activated which hinders the replication of the virus and prevents its dissemination throughout the mosquito, thereby preventing its transmission to humans. Essentially, what the researchers have done is transfer genes from the human immune system to confer immunity to mosquitoes.  The researchers are testing methods to neutralize mosquitoes against other viruses they spread.

This opens up a whole new approach to interrupt mosquito-borne human diseases.  Mosquitoes are among the deadliest killers on the planet because they are the messengers that transmit deadly diseases.  Until now, the only real solution has been to kill the messenger.  The new approach may be a better way to deal with a serious problem.

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Mosquitoes engineered to repel dengue virus

Photo, posted June 20, 2014, courtesy of Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

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