gene editing

An anti-malaria breakthrough

August 26, 2025 By EarthWise Leave a Comment

The deadliest animal in the world is the mosquito. Mosquitos infected 263 million people with malaria in 2023, leading to 600,000 deaths, 80% of which were children. Malaria is caused by infection from Plasmodium parasites. The parasites are transmitted to humans from the bite of infected female mosquitos.

Researchers at the University of California San Diego, Johns Hopkins University, UC Berkeley, and the University of Sāo Paulo have developed a new method that genetically blocks mosquitos from transmitting malaria.

The study was published in the journal Nature. They used gene editing to change a single molecule within mosquitos. The genetically altered mosquitos can still bite people with malaria and can still acquire parasites from their blood, but the parasites can no longer be spread to other people. The switching of one specific amino acid known as L224 with a genetic alternative called Q224 prevents malarial parasites from reaching the salivary glands of the mosquito, thereby preventing the spread of infection. In extensive tests, the researchers found that while the genetic switch disrupted the parasite’s infection capabilities, the mosquitos’ normal growth and reproduction remained unchanged.

The hope is that the replacement of a single amino acid in mosquitoes that prevents them from being infected with malarial parasites is a beneficial trait that can spread throughout a mosquito population. The researchers believe that the trait can be spread across diverse mosquito species and populations and can pave the way for adaptable, real-world strategies to control malaria.

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Stealth Genetic Switch in Mosquitoes Halts Malaria Spread

Photo, posted June 20, 2014, courtesy of John Tann via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio

Almost a dire wolf

April 22, 2025 By EarthWise Leave a Comment

Researchers around the world are working on what some call the ‘de-extinction’ of iconic animals of the past such as the wooly mammoth, the dodo, and the Tasmanian tiger. The idea is to decipher the genome from DNA of preserved specimens and, using the tools of modern genetic engineering and cloning technology, alter the DNA of closely related modern species to recreate the extinct species.

A company called Colossal Biosciences recently announced that it has brought back the dire wolf, a species that has been extinct for 10,000 years. Dire wolves have white coats and are larger than modern wolves, have more powerful shoulders, a wider head, and larger teeth and jaws. Colossal is now raising three wolves they have engineered at a 2,000-acre site at an undisclosed location.

The wolves were created by taking the DNA of modern grey wolves and editing 14 genes substituting ones from ancient dire wolf specimens. Wolves have about 19,000 genes, so the changes from the grey wolf genome are very minor but enough to produce an animal that looks just like a dire wolf. But is it a dire wolf?

It really isn’t. Ancient DNA is always greatly damaged. Only parts of it survive. We don’t actually have the complete genome of the dire wolf. What we have is bits and pieces that, thanks to modern technology, allow us to produce a phenotype of a dire wolf; that is, an animal with the same observable features.

Whether this accomplishment is a worthwhile and appropriate thing to do is a question that continues to be debated.

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The Return of the Dire Wolf

Photo courtesy of Colossal Laboratories & Biosciences.

Earth Wise is a production of WAMC Northeast Public Radio

Assisting Evolution | Earth Wise

March 11, 2021 By EarthWise Leave a Comment

As plants and animals around the world grapple with climate change, invasive species, disease, and other threats, conservationists grapple with the issue of what it means to protect what is natural and how far to go to prevent extinctions.

Australia is where many of these issues have risen to the forefront. Imported mammals – particularly cats and foxes – have decimated many of Australia’s indigenous marsupials. Much of the focus for decades has been on killing off the invaders and cordoning off protected animals. In recent years, however, there have been efforts to expose prey animals to limited numbers of predators to develop prey populations that are better equipped to survive among predators. Getting rid of all the predators is not realistic. Saving species may require helping them to adapt.

On the Great Barrier Reef, where half its coral populations have perished because of rising water temperatures, scientists are breeding corals that are more heat tolerant. They are even considering the use of gene editing technology to “assist evolution” in developing corals that can survive in a changing world.

At SUNY College of Environmental Science and Forestry in Syracuse, New York, researchers have produced a genetically modified American chestnut tree that is resistant to chestnut blight, the fungal pathogen that killed off nearly every chestnut tree in North America in the early 20^th century.

The idea of conservation is to protect what is natural in our world. However, at a time when there are unprecedented threats to so many species, the distinction between what is natural and what is artificial may no longer provide a sound guide to what should be done to protect life on earth.

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Assisting Evolution: How Far Should We Go to Help Species Adapt?

Photo, posted November, 2000, courtesy of Bernard Dupont via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Speed Breeding Of Crops

January 4, 2019 By EarthWise Leave a Comment

A technique pioneered by NASA for the purpose of growing plants extra-terrestrially is now being applied here on earth to fast-track improvements in a range of crops. The technique, known as speed breeding, has been adapted for use by British and Australian researchers on a scale ranging from vast greenhouses to desktop growth chambers.

Speed breeding uses enhanced LED lighting and day-long regimes of up to 22 hours to optimize photosynthesis and promote rapid growth of crops. By speeding up the breeding cycle of plants,it is possible, for example, to grow six generations of wheat in a year compared with two generations using traditional breeding methods.

With shortened breeding cycles, genetic improvements such as yield gain, disease resistance and climate resistance can be fast-tracked in crops such as wheat, barley, chickpeas, various Brassica species, oil seed rape and peas.

The ability to do this in compact desktop chambers permits cutting-edge research to be performed inexpensively before being scaled up to large greenhouses.

Crop development is an increasingly important activity and speed breeding is increasingly attractive in light of the opposition in some quarters to modern gene-editing techniques to create GMO crops. Speed breeding allows crop improvements via anon-GMO route.

The new technique is already being applied in Australia, which is experiencing one of the worst droughts on record. It is being used to rapidly cycle genetic improvements to make crops more drought resilient.

Generation time in most plant species is a major bottleneck in applied research programs and breeding. Speed breeding can greatly reduce this bottleneck, allowing scientists to respond more quickly to emerging diseases, the changing climate and increased demand for specific plant traits.

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JIC joins European scientists to safeguard precision breeding

Photo, posted May 8, 2016, courtesy of Yair Aronshtam via Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.