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You are here: Home / Episode / Fighting Malaria With Gene-Drive Technology | Earth Wise

Fighting Malaria With Gene-Drive Technology | Earth Wise

June 8, 2020 By EarthWise Leave a Comment

Using malaria to fight malaria

Malaria continues to be a major health hazard throughout the tropical and subtropical regions of the world. There were 228 million cases of malaria in 2018 and over 400,000 deaths. 

Malaria is a mosquito-borne infectious disease spread by 40 of the world’s 3,500 mosquito species.  So, efforts to control mosquito populations are the primary strategy to eradicate malaria.

A team led by Imperial College London has created a genetic modification that distorts the sex ratio of a population of Anopheles gambiae mosquitoes using “gene drive” technology.  The modification works by using a DNA-cutting enzyme to destroy the X chromosome during the production of sperm, which leads to predominantly male offspring, since females require two X chromosomes.  The modification is coupled to a gene drive to allow it to spread through a population in a very effective way.  A gene drive is a genetic engineering technology that propagates a particular modification by assuring that a specific form of a gene (or allele) will be transmitted with far more than the natural 50% probability.

The result of this is that mosquitoes produce more male offspring, eventually leading to no females being born and a total collapse in the population. The mosquitoes studied are the main malaria vector in sub-Saharan Africa.  The hope is that mosquitoes carrying a sex-distorter gene drive would be released in the future, spreading the male bias with local malaria-carrying populations and causing them to collapse.  Only female mosquitoes bite and take blood meals.  If the gene drive technology works in the field, it could be a game-changer in the fight to eliminate malaria.

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Malaria mosquitoes eliminated in lab by creating all-male populations

Photo, posted June 20, 2014, courtesy of Flickr.

Earth Wise is a production of WAMC Northeast Public Radio.

Tagged With: africa, allele, blood meals, chromosomes, Climate Change, collapse, disease, environment, enzyme, eradication, femals, gene, gene-drive, genetic modification, global problem, hazard, Health, infectious disease, malaria, males, modification, mosquitoes, offspring, population, probability, sub-saharan, subtropical, Technology, tropical

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